design, construction and calibration of a laser ionization time-of-flight mass spectrometer

Design, Construction and Calibration of a Laser Ionization Time-of-Flight Mass Spectrometer

A time-of-flight mass spectrometer (TOF-MS) developed in our laboratory at Isfahan University of Technology is described here. The TOF-MS instrument uses laser as the ionization source which provides an opportunity to investigate the ions formed in laser ablation or desorption. The TOF-MS has an ionization chamber containing an accelerator and an ion lens to focus the ions into a one meter line...

A field-deployable, chemical ionization time-of-flight mass spectrometer

We constructed a new chemical ionization timeof-flight mass spectrometer (CI-TOFMS) that measures atmospheric trace gases in real time with high sensitivity. We apply the technique to the measurement of formic acid via negative-ion proton transfer, using acetate as the reagent ion. A novel high pressure interface, incorporating two RF-only quadrupoles is used to efficiently focus ions through f...

Development of a Portable Single Photon Ionization-Photoelectron Ionization Time-of-Flight Mass Spectrometer

A vacuum ultraviolet lamp based single photon ionization- (SPI-) photoelectron ionization (PEI) portable reflecting time-of-flight mass spectrometer (TOFMS) was designed for online monitoring gas samples. It has a dual mode ionization source: SPI for analyte with ionization energy (IE) below 10.6 eV and PEI for IE higher than 10.6 eV. Two kinds of sampling inlets, a capillary inlet and a membra...

matrix-assisted laser desorption/ionization time of flight mass spectrometry: a new guide to infectious disease

Design and development of a Reflectron Time-of-Flight Mass Spectrometer (RTOF -MS) for Resonance Ionization Mass Spectrometry (RIMS)

Applications of Time-of-Flight Mass Spectrometer (TOF -MS) for RIMS are quite well known. Enhancement in mass resolution of RIMS signals is expected by replacing the TOF-MS with RTOF -MS. We have designed such a RTOF instrument as part of our RIMS set up. The mass spectrometer designed is based on optimization using an ion simulation software with improved resolution and sensitivity. The mass s...

Isoelectric Focusing, Matrix-assisted Laser Desorption/ionization Time-of- Flight Mass Spectrometry, Electrospray Ionization Mass Spectrometry

LEVEL: INTERMEDIATE D iscovery, development, and commercialization of novel biologics frequently involve collaboration between two or more companies. In the context of these business relationships, transfer of technology from one institution to another is a crucial step that needs to be executed f lawlessly and rapidly. Follow-up activities usually include the development of productive, reliabl...